DEEPGEN™
R&D Solution

Fast-track your liquid biopsy research with a solution specifically designed for deep genomics and AI data exploration.
Get in Touch
A Turnkey SolutionAdvantagesResearch Opportunities

DEEPGEN™ R&D Solution

Fast-track your liquid biopsy research with a solution specifically designed for deep genomic and AI data exploration.
Get in Touch

A turnkey liquid biopsy research solutiono

DEEPGEN is a new option for anyone conducting liquid biopsy research to investigate somatic mutational patterns with next-generation sequencing (NGS).

FASTo

7-day turn around after blood sample submission

LOW COSTo

$950 per sample

No minimum Sample batch size starting with a single sample.

ULTRA-DEEPo

0.1% validated MAF

Detecting a single mutant copy in a thousand wild type copies of background

PROVENo

Over 200 billion NGS reads to-date in clinical liquid biopsy trials

The 4 steps of the DEepgen Solutiono

Combine any or all steps to fast-track your research

1 DEEPGEN NEXT-GENERATION SEQUENCING (NGS)

Ultra-deep sequencing allows detection of extremely rare mutational events that may be indicative of disease presence or recurrence. DEEPGEN utilizes the most advanced techniques to ensure that data output is the highest possible quality. DEEPGEN’s NGS process is outlined below:

  • Receive standard blood sample (10-20ml)
  • Nucleic acid extraction using the Qiagen QIAsymphony and an innovative extraction technology based on industry leading chemistry that achieves high efficiencies from standard input volumes of blood
  • Run DEEPGEN assay on Illumina NovaSeq 6000


The DEEPGEN panel is unique in that the assay design provides both industry leading technical sensitivity and specificity in a large pan-cancer detection custom designed panel. The assay is comprised of a target panel of 258 genes identified to be related to cancer - through a proprietary machine learning algorithm. DEEPGEN ensures industry leading analytical and clinical performance. A combination of both proprietary and consensus markers, the panel contains genes in the U.S. National Comprehensive Cancer Network (NCCN) Guidelines, lung cancer and colorectal cancer (CRC), and emerging cancer biomarkers. DEEPGEN achieves a true limit of detection of 1/1000 genome copies, better than any other available technology to date.

Technologies Used: Illumina NovaSeq 6000, Qiagen QIAsymphony, DEEPGEN custom assay

Output: FastQFiles

2 Deepgen mutational Detection

Using ultra-deep sequencing and proprietary analyses, extremely low level mutations can be detected and separated from the background noise of random mutations. Each base is evaluated to determine true pathogenic mutations from those that are nonpathogenic or due to sequencing errors.

Technologies Used: DEEPGEN core engine (Deep signal processing, noise reduction, error correction, machine learning and cloud enabled bioinformatics system)

Output: Mutational Patterns

3 DEEPGEN AI disease Recognition

DEEPGEN AI disease recognition technology utilizes both classical machine learning, and deep learning layers that have the ability to recognize relationalpatterns between individual features that correlate with certain disease profiles. DEEPGEN covers 15 cancer types including breast, colorectal, lung, ovarian, prostate, and more. This machine learning and AI infrastructure is what ultimately determines disease profiles in clinical samples that can then be used for multiple applications ranging from drug development to more general healthcare solutions.

Technologies Used: Deep learning networks, DEEPGEN disease data sets from clinical trials

Output: Disease patterns and detection diagnostics

4 DEEPGEN Analytics

DEEPGEN analytics allows the user to understand mutational patterns by gene summaries, gene profiles including onco and tumor suppressor gene descriptions for mutations that were contained in the sample, as well as detected mutational targets that are FDA approved for guiding treatment decisions. DEEPGEN analytics also provides quality control tools that allow sample quality variables such as cfDNA input levels, plasma volumes, sequencing depth and total DNA copy counts by targets and amplicons. Additionally, easy overviews over clinical data allows for correlation between genomic and laboratory findings with clinical and demographic variables such as age, gender, ethnicity as well as comorbidities and diagnoses.

Get DEEPGEN

A superior solution to accelerate your researcho

The current standard to develop custom-built solutions which can take years to build, are costly and have limited accuracy.

DEEPGEN is a solution to outperform any custom-built research panel. You can immediately conduct research and save more money with every single run.

A superior solution to accelerate your research.

The current standard to conduct research is custom built solutions which take years to build and cost hundreds and thousands of dollars and offer limited accuracy.

DEEPGEN is your custom solution to outperform any custom panel in accuracy be immediately ready to research and save more money with every single run.

Setup Time total
SEtup Time per run
Cost Per Run

cfDNA Extraction Optimization
Assay Development
NGS Refinement
Bioinformatics Development

Time total

Assay Development
NGS Refinement
Bioinformatics Development

Cost Total

4 hours
8 hours
4 hours
30 days

32 days

Included
Included
Included
Included

7 Days (turnaround)

Included
Included
Included
Included

$950

3 months
6 months
3 months
6 months

18 months

$90,000
$30,000
$45,000

$165,000

Included
Included
Included
Included

1 day

Detects to 0.1% validated MAF
258

cfDNA Extraction
Library Preparation (per batch)
NGS
Bioinformatics Analysis

time total per run

cfDNA Extraction
Library Preparation (per batch)
NGS
Bioinformatics Analysis

Cost total per run

2. Cost Advantage

3. Accuracy Advantage

Setup Cost total

Included
Included
Included

$0 (included)

$80
$300
$600
$250

$1,130
Custom BuilT
Custom BuilT
DeepGEn
Custom BuilT

1. Time Advantage

Limit of Detection
Genes Covered

Detects down to 1% MAF
(variable)

DeepGEn
DeepGEn
Custom BuilT
DEEPGEN
Setup
Per Run
Per Run

cfdna Extraction optimization
Assay Development
NGS Refinement
Bioinformatics development

Time to get started

Assay Development
NGS Refinement
Bioinformatics development

Total

4 hours
8 hours
4 hours
30 days

32 days

Included
Included
Included
Included

7 Days (turnaround)

Included
Included
Included
Included

$950

3 months
6 months
3 months
6 months

18 months

$90,000
$30,000
$45,000

$165,000

Included
Included
Included
Included

1 day

Detects to 0.1% validated MAF
258

cfdna Extraction
Library preparation (per batch)
NGS
Bioinformatics analysis

Total

cfdna Extraction
Library preparation (per batch)
NGS
Bioinformatics analysis

Total

2. Cost Advantage

3. Accuracy Advantage

Setup

Included
Included
Included

0 (included)

$80
$300
$600
$250

$1,130

1. Time Advantage

Limit of Detection
Genes Covered

Detects down to 1% MAF
(variable)

1. Time Advantage

Setup

cfdna Extraction optimization
Assay Development
NGS Refinement
Bioinformatics development

Time to get started
Per Run

cfdna Extraction
Library preparation (per batch)
NGS
Bioinformatics analysis

Total

3 months
6 months
3 months
6 months

18 months


4 hours
8 hours
4 hours
30 days

32 days

Included
Included
Included
Included

1 day


Included
Included
Included
Included

7 days (turnaround)

2. Cost Advantage

Setup

Assay Development
NGS Refinement
Bioinformatics development

Total
Per Run

cfdna Extraction
Library preparation (per batch)
NGS
Bioinformatics analysis

Total

$90,000
$30,000
$45,000

$165,000


$80
$300
$600
$250

$1,130

Included
Included
Included

0 (included)


Included
Included
Included
Included

$950

3. Accuracy Advantage

Limit of Detection
Genes Covered

Detects down to 1% MAF
(variable)

Detects to 0.1% validated MAF
258

cfdna Extraction optimization

cfdna Extraction

NGS

Bioinformatics analysis

TIME Total

Library preparation (per batch)

Assay Development

NGS Refinement

Bioinformatics development

3 months

4 hours

8 hours

Included

Setup TIME TOTAL
Custom Built
DEEPGEN

6 months

Included

Included

3 months

6 months

18 months

Included

Included

Included

Time to get started
TIME Per Run

4 hours

30 days

32 days

Included

Included

7 Days (turnaround)
1 Day

1. Time Advantage

cfdna Extraction optimization

cfdna Extraction

NGS

Bioinformatics analysis

TIME Total

Library preparation (per batch)

Assay Development

NGS Refinement

Bioinformatics development

3 months

4 hours

8 hours

Included

Setup TIME TOTAL
Custom Built
DEEPGEN

6 months

Included

Included

3 months

6 months

18 months

Included

Included

Included

Time to get started
TIME Per Run

4 hours

30 days

32 days

Included

Included

7 Days (turnaround)
1 Day

1. Time Advantage

cfdna Extraction optimization

cfdna Extraction

NGS

Bioinformatics analysis

COST Total

Library preparation (per batch)

NGS Refinement

Bioinformatics development

$90,000

$80

$300

Included

Setup

$30,000

Included

Included

$45,000

$165,000

Included

Included

COST to get started
COST Per Run

$600

$250

$1,130

Included

Included

$950

2. Cost Advantage

Custom Built
DEEPGEN
$0 (included)

Limit of Detection

Genes Covered

Detects down to 1% MAF

Detects to 0.1% validated MAF

(variable)

258

3. Accuracy Advantage

Custom Built
DEEPGEN
Custom Built
DEEPGEN

Limit of Detection

Detects down to 1% MAF

Detects to 0.1% validated MAF

Genes Covered

(variable)

258

3. Accuracy Advantage

Deepgen Analyzes 258 genes identified to be related to cancero

The genes and mutations tested have been previously demonstrated to be involved in cancer. We identified this core spectrum of genes and mutations as the most likely candidates as biomarkers for the development and/or recurrence of cancer.

PUShing the liquid biopsy frontiero

DEEPGEN powered liquid biopsy offers dozens of different research applications across 5 clinical areas and 15 cancer types.

Ready to fast-track your research?

Our team is ready to help